1. Early-stage or in situ cancer: Chemotherapy may not be necessary, and it could have negative effects.
2. Elderly patients or those with comorbidities: This group has low tolerance and is not suitable for chemotherapy.
3. Tumors that do not require chemotherapy: Some cancers, like renal clear cell carcinoma, differentiated thyroid cancer, and gastrointestinal stromal tumors, may not respond well to chemotherapy.
4. Patients with drug resistance: If patients have already undergone multiple chemotherapy treatments and developed drug resistance, it's best to explore alternative treatment methods.
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