Title: AB blood type and the risk of cognitive decline Introduction: Mr. Li, a 49-year-old businessman, was diagnosed with early-stage Alzheimer's disease, causing a significant impact on his and his wife's lives. 1. AB blood type and accelerated cognitive decline: Research published in JAMANeurology suggests that individuals with AB blood type have an 82% higher probability of experiencing cognitive decline compared to other blood types.

This is attributed to higher levels of the factor VIII protein, which can lead to impaired brain function and increased risk of dementia. 2. Lower risk for individuals with blood type O: People with blood type O have a lower risk of developing cognitive impairments. This is because they have more grey matter in areas of the brain responsible for memory, resulting in stronger neural connections and better memory function.

Prevention strategies to reduce the risk of dementia: Director Niu Guowei of the Beijing Xiaotangshan Hospital's Aerobic Exercise Center suggests several preventive measures: 1. Manage hypertension, hyperlipidemia, and hyperglycemia: Keeping blood pressure between 90-140mmHg, maintaining a healthy weight, and controlling blood glucose levels are crucial. Regular monitoring of these parameters, especially after the age of 35, is recommended.

2. Engage in regular physical exercise: Studies show that older adults who exercise regularly have a lower risk of developing dementia. Engaging in at least three sessions of aerobic exercise, such as tai chi or swimming, for more than 20 minutes per week is beneficial. 3. Stimulate the brain and engage in social activities: To keep the brain active, individuals should participate in activities such as reading, socializing, playing chess, and mahjong.

Regular mental stimulation helps maintain cognitive function.

4. Adopt a healthy lifestyle: Maintaining good sleep habits, refraining from smoking and excessive alcohol consumption, and maintaining a balanced diet are important. Consuming brain-healthy foods is also recommended. Young adults at higher risk: Recent research in Neurology indicates that individuals with early adulthood cardiovascular risk factors, such as high BMI, high blood pressure, and abnormal fasting blood glucose levels, are more likely to develop cognitive impairments later in life.

Recognizing signs in older adults: As Alzheimer's disease progresses, individuals may exhibit common phrases that raise concern: 1. "What did you say? I forgot." 2. "Where am I? Why am I here?" 3. "Where did I put that?" 4. "I don't know how to use this." Conclusion: While there is no cure for Alzheimer's disease, early detection and proactive prevention efforts are crucial.

Individuals with AB blood type and certain cardiovascular risk factors should take measures to reduce their risk of cognitive decline. Providing care, monitoring for signs of dementia, and seeking medical attention are essential for older adults with potential memory issues. (157 words)