Low-density lipoprotein cholesterol (LDL-C) is commonly known as "bad cholesterol" and it is recommended to keep it low. High levels of LDL-C can accelerate the progression of atherosclerosis and increase the risk of diseases like stroke and heart attack. How is LDL-C formed and how can we prevent its oxidation? 

1. Formation of LDL-C: Cholesterol in the body is synthesized by the liver and obtained from food. LDL-C acts as a transporter, delivering cholesterol to tissues and organs for cell membrane and hormone synthesis. When LDL-C enters the blood vessels and encounters inflammatory factors, it undergoes oxidative modification and transforms into LDL-C.

2. Formation of Plaque: Oxidized LDL-C attracts macrophages, which engulf the LDL-C particles, forming foam cells.

The accumulation of foam cells leads to the formation of lipid plaques in the endothelium of blood vessels. 

Preventing LDL-C Oxidation：
1. Control of LDL-C: To reverse plaque formation, LDL-C levels should be reduced and oxidation prevented. The Chinese Blood Lipid Management Guidelines recommend lowering LDL-C to 1.

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