1. Age Factor: Aging leads to a gradual weakening of self-regulation functions in the brain, reduced metabolism of glucose and oxygen, and increased vulnerability of brain blood vessels to damage, ultimately leading to the onset of Alzheimer's disease.
2. Genetic Factor: Individuals with a family history of Alzheimer's disease have a significantly higher risk of developing the disease compared to the general population, and nearly 60% of their direct relatives are also at risk at a certain age.
3. Disease Factor: Common diseases such as diabetes, stroke, head trauma, hyperlipidemia, hypertension, cerebral hemorrhage, heart failure, myocardial infarction, and head injuries can lead to Alzheimer's disease.
4. Smoking: Long-term smoking exposes the brain tissue to harmful substances present in cigarettes, leading to varying degrees of atrophic changes. Furthermore, smoking not only increases the risk of Alzheimer's disease but also contributes to various serious cerebrovascular diseases.
