Men have a shorter lifespan compared to women, and recent research suggests that the presence of the Y chromosome may be a contributing factor.

1. Cancer is More Prevalent in Men: Data shows that in the top 10 countries with the highest cancer rates, the risk of cancer is consistently higher in men. Factors such as lifestyle habits, weaker immune systems, and hormone differences contribute to this disparity.

2. The Role of the Y Chromosome in Cancer: New research suggests that the Y chromosome may be responsible for the increased risk of cancer in males. Studies have shown that genes on the Y chromosome can promote tumor invasion and immune evasion.

3. Y Chromosome Loss and its Impact on Cancer: Loss of the Y chromosome has been observed in various types of cancer, including bladder cancer. Tumors with Y chromosome loss exhibit more aggressiveness.

4. Y Chromosome Loss and Immunotherapy: Tumors with Y chromosome loss are more responsive to certain types of immunotherapy, providing potential treatment options.